By Jones and Bartlett Publishers
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Extra info for 2011 Nurse's Drug Handbook
If patient is receiving acarbose and a sulfonylurea or insulin to enhance glucose control, check blood glucose level often, as appropriate. • Store drug in sealed container in cool environment. • Expect to decrease dosage to control GI upset. • Monitor glycosylated hemoglobin level as ordered every 3 months for first year to evaluate glucose control and patient compliance. • Monitor hematocrit and serum AST level every 3 months during first year of therapy and periodically thereafter, as ordered, because acarbose may decrease hematocrit and increase serum AST level.
V. 22-micron filter. M. injections, venipunctures, and use of indwelling urinary catheters, NG tubes, and automatic blood pressure cuffs during therapy to prevent bleeding. V. access device to obtain blood samples. • Watch for GI, GU, and retroperitoneal bleeding and bleeding at puncture sites. WARNING If hemorrhage occurs, prepare to stop infusion immediately. Expect to treat severe thrombocytopenia with platelet transfusions if needed. • Monitor patient for hypersensitivity reactions, such as rash, pruritus, wheezing, and dysphagia from laryngeal edema.
125 mcg/kg/ min by continuous infusion for 12 hr. Maximum: 10 mcg/min. V. INFUSION OR INJECTION Adults. 250-mcg/kg by bolus; then 10 mcg/ min by continuous infusion over 18 to 24 hr, concluding 1 hr after PTCA. V. Peak Duration Unknown Unknown 48 hr Mechanism of Action Binds to glycoprotein IIb/IIIa receptor sites on the surface of activated platelets. Circulating fibrinogen can bind to these receptor sites and link platelets together, 92381_Axxx_p0017-0122 6/1/10 10:05 PM Page 19 acamprosate calcium forming a clot that eventually blocks a coronary artery.