By Jose A. Plaza, Victor G. Prieto
This ebook presents a complete, cutting-edge account of the function of immunohistochemistry within the prognosis of epidermis tumors, that's the most important provided that overlapping histologic positive aspects and strange morphologic adjustments can result in enormous diagnostic uncertainty. The ebook experiences intimately the sensitivity and specificity of usually on hand antibodies and their development of immunostaining. readers will research while to reserve antibodies and the way to interpret findings. moreover, prognostic markers are evaluated and emphasis put on the pitfalls quite often encountered while comparing those neoplasms. The textual content is complemented by means of a wealth of outstanding pictures. important histograms and algorithms are incorporated, and transparent information is equipped at the program and interpretation of much less everyday antibodies and immunostains. Applied Immunohistochemistry within the overview of dermis Neoplasms will function a very worthy source for working towards dermatopathologists and pathologists.
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Additional info for Applied Immunohistochemistry in the Evaluation of Skin Neoplasms
2013;52(3):378–80. 78. Sigel JE, et al. The utility of cytokeratin 5/6 in the recognition of cutaneous spindle cell squamous cell carcinoma. J Cutan Pathol. 2001;28(10):520–4. 79. Gray Y, et al. Squamous cell carcinoma detected by high-molecular-weight cytokeratin immunostaining mimicking atypical fibroxanthoma. Arch Pathol Lab Med. 2001;125(6):799–802. 80. Heintz PW, White Jr CR. Diagnosis: atypical fibroxanthoma or not? Evaluating spindle cell malignancies on sun damaged skin: a practical approach.
Desmin, synaptophysin, and chromogranin are usually negative . Malignant Tumors Syringocystadenocarcinoma Papilliferum Syringocystadenocarcinoma papilliferum (SCACP) is an extremely rare cutaneous adnexal neoplasm representing the malignant counterpart of SCAP from which it usually evolves . To date, less than 30 cases have been reported, and of those, only three had locoregional metastases [87–89]. The majority of cases reported were located in the head and neck region, or less commonly the perineal area and extremities of middle aged to elderly individuals.
H. A. Plaza 73. Cassarino DS, Derienzo DP, Barr RJ. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification--part two. J Cutan Pathol. 2006;33(4):261–79. 74. Ackerman LV. Verrucous carcinoma of the oral cavity. Surgery. 1948;23(4):670–8. 75. Nakamura Y, et al. Verrucous carcinoma of the foot diagnosed using p53 and Ki-67 immunostaining in a patient with diabetic neuropathy. Am J Dermatopathol. 2015;37(3):257–9. 76. Adegboyega PA, Boromound N, Freeman DH. Diagnostic utility of cell cycle and apoptosis regulatory proteins in verrucous squamous carcinoma.