By Roberta A. Gottlieb
Autophagy in well-being and Disease deals an outline of the most recent examine in autophagy with a translational emphasis. This booklet takes medical study in autophagy a step extra and provides built-in content material with developments in autophagy from mobilephone biology and biochemical learn to scientific remedies. an important reference for the bookshelf of clinical and medical researchers and scholars, Autophagy in healthiness and Disease offers top of the range, respected info on autophagy, permitting the reader easy access to the main appropriate information.
- Discusses present knowing of the jobs of autophagy in healthiness and disease
- Covers the historical past of autophagy, the improvement of instruments and therapeutics to degree and modulate autophagy, and autophagy in tissues and affliction processes
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Extra info for Autophagy in Health and Disease
The Journal of Neuroscience: the official journal of the Society for Neuroscience 2003;23(4):1254e64. 129. Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, et al. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 2007;131(6):1149e63. 130. Simonsen A, Birkeland HC, Gillooly DJ, Mizushima N, Kuma A, Yoshimori T, et al. Alfy, a novel FYVEdomain-containing protein associated with protein granules and autophagic membranes. J Cell Sci 2004;117(Pt 18):4239e51.
ORGAN SYSTEMS REFERENCES 39 36. McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, et al. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 2004;109:3050e5. 37. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Richardson JA, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest 2007;117:1782e93. 38. Knaapen MW, Davies MJ, De Bie M, Haven AJ, Martinet W, Kockx MM. Apoptotic versus autophagic cell death in heart failure.
These findings suggest that autophagy may enable thymic epithelial cells to present self-antigens to developing thymocytes during antigen selection. In addition, II. ORGAN SYSTEMS AUTOPHAGY AND DEVELOPMENT 45 Schmid et al16 noted considerable autophagy in immature dendritic cells, which have been implicated in the induction of peripheral tolerance25. To determine if autophagy in thymic epithelial cells influences T cell selection, thymi from either Atg5-deficient or wild type mice were engrafted into a variety of different T cell receptor transgenic mice26.