By Ewold W Dijk, Ben L. Feringa, Gerard Roelfes (auth.), Thomas R. Ward (eds.)
In order to satisfy the ever-increasing calls for for enantiopure compounds, heteroge- ous, homogeneous and enzymatic catalysis advanced independently long ago. even if all 3 methods have yielded industrially workable techniques, the latter are the main frequent and will be considered as complementary in lots of respects. regardless of the growth in structural, computational and mechanistic reviews, even if, so far there isn't any common recipe for the optimization of catalytic tactics. hence, a trial-and-error procedure is still most important in catalyst discovery and optimization. With the purpose of complementing the well-established fields of homogeneous and enzymatic catalysis, organocatalysis and synthetic metalloenzymes have loved a contemporary revival. man made metalloenzymes, that are the focal point of this e-book, consequence from comb- ing an energetic yet unselective organometallic moiety with a macromolecular host. Kaiser and Whitesides prompt the potential of growing synthetic metallo- zymes as in the past because the past due Nineteen Seventies. even if, there has been a frequent trust that proteins and organometallic catalysts have been incompatible with one another. This seriously hampered learn during this region on the interface among homogeneous and enzymatic catalysis. due to the fact that 2000, in spite of the fact that, there was a turning out to be curiosity within the box of man-made metalloenzymes for enantioselective catalysis. the present state-of-the-art and the potential of destiny improvement are p- sented in 5 well-balanced chapters. G. Roelfes, B. Feringa et al. summarize examine counting on DNA as a macromolecular host for enantioselective catalysis.
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Mn(corrole) and Cu(phthalocyanine) are inserted into SA by non-covalent interactions and the composites catalyze asymmetric sulfoxidation and Diels-Alder reactions with up to 74 and 98% ee, respectively (Fig. 2c) [28, 30]. Since the heme is coordinated to Tyr161 in the albumin cavity, determined by X-ray crystal structure , it is expected that both Mn(corrole) and Cu(phtalocyanine) are also bound to albumin with the same coordination. The incorporation of synthetic metal complexes in protein cavities using these methods is a powerful approach for asymmetric catalytic reactions.
6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. Lu Y (2006) Angew Chem Int Ed 45:5588–5601 Steinreiber J, Ward TR (2008) Coord Chem Rev 252:751–766 Thomas CM, Ward TR (2005) Chem Soc Rev 34:337–346 Uchida M, Klem MT, Allen M, Suci P, Flenniken M, Gillitzer E, Varpness Z, Liepold LO, Young M, Douglas T (2007) Adv Mater 19:1025–1042 Ueno T, Abe S, Yokoi N, Watanabe Y (2007) Coord Chem Rev 251:2717 Ueno T, Yokoi N, Abe S, Watanabe Y (2007) J Inorg Biochem 101:1667 Akabori S, Sakurai S, Izumi Y, Fujii Y (1956) Nature 178:323–324 Wilson ME, Whitesides GM (1978) J Am Chem Soc 100:306–307 Abe S, Ueno T, Reddy PAN, Okazaki S, Hikage T, Suzuki A, Yamane T, Nakajima H, Watanabe Y (2007) Inorg Chem 46:5137–5139 Alexeev D, Zhu HZ, Guo ML, Zhong WQ, Hunter DJB, Yang WP, Campopiano DJ, Sadler PJ (2003) Nat Struct Biol 10:297–302 Calderone V, Casini A, Mangani S, Messori L, Orioli PL (2006) Angew Chem Int Ed 45:1267–1269 Debreczeni JE, Bullock AN, Atilla GE, Williams DS, Bregman H, Knapp S, Meggers E (2006) Angew Chem Int Ed 45:1580–1585 Hu YZ, Tsukiji S, Shinkai S, Oishi S, Hamachi I (2000) J Am Chem Soc 122:241–253 McNae IW, Fishburne K, Habtemariam A, Hunter TM, Melchart M, Wang FY, Walkinshaw MD, Sadler PJ (2004) Chem Commun 2004:1786–1787 Satake Y, Abe S, Okazaki S, Ban N, Hikage T, Ueno T, Nakajima H, Suzuki A, Yamane T, Nishiyama H, Watanabe Y (2007) Organometallics 26:4904–4908 Ueno T, Ohashi M, Kono M, Kondo K, Suzuki A, Yamane T, Watanabe Y (2004) Inorg Chem 43:2852–2858 Ueno T, Koshiyama T, Ohashi M, Kondo K, Kono M, Suzuki A, Yamane T, Watanabe Y (2005) J Am Chem Soc 127:6556–6562 Ueno T, Yokoi N, Unno M, Matsui T, Tokita Y, Yamada M, Ikeda-Saito M, Nakajima H, Watanabe Y (2006) Proc Natl Acad Sci USA 103:9416–9421 Zhong WQ, Alexeev D, Harvey I, Guo ML, Hunter DJB, Zhu HZ, Campopiano DJ, Sadler PJ (2004) Angew Chem Int Ed 43:5914–5918 Zunszain PA, Ghuman J, Komatsu T, Tsuchida E, Curry S (2003) BMC Struct Biol 3:6–14 Hayashi T, Hitomi Y, Ando T, Mizutani T, Hisaeda Y, Kitagawa S, Ogoshi H (1999) J Am Chem Soc 121:7747–7750 Hayashi T, Murata D, Makino M, Sugimoto H, Matsuo T, Sato H, Shiro Y, Hisaeda Y (2006) Inorg Chem 45:10530–10536 Carey JR, Ma SK, Pfister TD, Garner DK, Kim HK, Abramite JA, Wang Z, Guo Z, Lu Y (2004) J Am Chem Soc 126:10812–10813 Ohashi M, Koshiyama T, Ueno T, Yanase M, Fujii H, Watanabe Y (2003) Angew Chem Int Ed 42:1005–1008 Collot J, Gradinaru J, Humbert N, Skander M, Zocchi A, Ward TR (2003) J Am Chem Soc 125:9030–9031 Letondor C, Humbert N, Ward TR (2005) Proc Natl Acad Sci USA 102:4683–4687 Komatsu T, Ohmichi N, Zunszain PA, Curry S, Tsuchida E (2004) J Am Chem Soc 126:14304–14305 Mahammed A, Gross Z (2005) J Am Chem Soc 127:2883–2887 Marchetti M, Mangano G, Paganelli S, Botteghi C (2000) Tetrahedron Lett 41:3717–3720 Reetz MT, Jiao N (2006) Angew Chem Int Ed 45:2416–2419 Hunter TM, McNae IW, Liang XY, Bella J, Parsons S, Walkinshaw MD, Sadler PJ (2005) Proc Natl Acad Sci USA 102:2288–2292 Aime S, Frullano L, Crich SG (2002) Angew Chem Int Ed 41:1017–1019 Ishii D, Kinbara K, Ishida Y, Ishii N, Okochi M, Yohda M, Aida T (2003) Nature 423:628–632 42 S.
Unno M, Chen H, Kusama S, Shaik S, Ikeda-Saito M (2007) J Am Chem Soc 129:13394–13395 79. Koshiyama T, Yokoi N, Ueno T, Kanamaru S, Nagano S, Shiro Y, Arisaka F, Watanabe Y (2008) Small 4:50–54 80. Ueno T, Koshiyama T, Tsuruga T, Goto T, Kanamaru S, Arisaka F, Watanabe Y (2006) Angew Chem Int Ed 45:4508–4512 81. 1007/3418_2008_1 45 Manganese-Substituted a-Carbonic Anhydrase as an Enantioselective Peroxidase Qing Jing, Krzysztof Okrasa, and Romas J. Kazlauskas Abstract Carbonic anhydrase binds a zinc ion in a hydrophobic active site using the imidazole groups of three histidine residues.